Publications & technical resources

See how how Double Helix Optics technology can be used to quantitatively characterize extracellular vesicles in 3D .

See how DHO Double Helix PSFs enable efficient imaging of whole cells with speed and precision.

See how DHO-enabled 3D tracking combined with light sheet illumination is advancing our understanding of the relationship between chromatin dynamics and disease progression.

See how DHO-enabled 3D multi-color STORM is helping to understand the relationship between the spatial organization and signaling function of neural synapses.

See how 3D imaging with the SPINDLE® module and the double-helix phase mask is advancing the quest for new antibiotics.

Tilted light sheet microscopy with 3D point spread functions (TILT3D) combines a novel, tilted light sheet illumination strategy with long axial range point spread functions (PSFs) for low-background, 3D super-localization of single molecules as well as 3D super-resolution imaging in thick cells.

Jain and Wheeler et al. utilize the SPINDLE™ to visualize and characterize previously unseen stress granule cores. Stress granules are sub-cellular aggregates associated with ALS and Dementia. This ground-breaking study proposes a new model for the formation and dynamics of stress granules based on proteomic studies, in vitro isolation, and in vivo 3D Double Helix super-resolution imaging.