Nanoscale 3D imaging like never before
Unlock depth and precision with Double Helix Optics 3D imaging and sensing
Image credit: DHO
See life at the molecular level
Pushing beyond the limits of conventional imaging systems
Enabling instantaneous instantaneous 3D information capture
Rapidly delivering high-precision spatial biology datasets
Advancing the next generation of scientific research & innovation
Technology based on Nobel Prize-winning science
At the heart of Double Helix Optics is our engineered point spread function (ePSF) technology. Our team has expanded upon and refined a foundation of Nobel Prize-winning methods for super-resolution microscopy into a robust portfolio of spatial imaging solutions that enables the 3D imaging of structures and processes down to the molecular level. By capturing 2-20x the native depth of field with each image, scanning and stitching of axial slices is reduced or eliminated.
Image credit: DHO
Instantaneous 3D with SPINDLE® & 3DTRAX®
Our line of SPINDLE® modules and corresponding library of phase masks is the fastest way to achieve instantaneous 3D.
With offerings that include multi-channel systems that connect directly to existing microscopes to OEM integrations, the SPINDLE platform is designed to match your application. 3DTRAX® software works in tandem with SPINDLE to ensure accurate and precise data recovery for quantitative imaging results.
From super resolution to whole cell & live cell
Double Helix Optics solutions have been chosen by leading scientists to advance a broad array of scientific challenges.
Our technology can be used for investigations of live or fixed samples down to the molecular level, and is compatible with many common illumination modes and sample preparation techniques.
Image credit: S. Upton & W. Colomb, CU Boulder/DHO
What will you discover?
Image credit: M. Backlund, et al. (2014) Molecular Biology of the Cell.
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Spatial omics
Untangle the web of transcriptomics, genomics, and proteomics by efficiently imaging multiplexed, correlated, and dense emitters
3D super resolution
Visualize structures in 3D with instantaneous depth capture and precision an order of magnitude better than conventional microscopy, in x, y, and z
Leading modalities
Match our technology to your preferred techniques, from illumination to emission to measurement
Cell biology
Investigate the many facets of cells across spatial scales, subcellular structures to intercellular processes
Image credit: L. Möckl, et al. (2019) Developmental Cell.
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Disease discovery
Uncover mechanisms of disease and therapeutic pathways, from infectious bacteria to cancer to dementia
Image credit: S. Jain, et al. (2016) Cell. DOl
Neuroscience
Determine the interactions between key proteins and neural structures in the search to understand disease and develop new therapeutics
Image credit: DHO
3D particle tracking
Instantaneously track fast-moving, dynamic processes with large spatial excursions.
Image credit: DHO
Volumetric imaging
With our deep focus technology capture up to 5x the native depth of field and see an entire object of interest in focus in a single image