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Double Helix Optics Blog

Three-Dimensional Tracking of Interfacial Hopping Diffusion

The three-dimensional movement of molecules in liquids is well described by Brownian motion, however, the movement of molecules near interfaces is not as well understood, especially in the case of how molecules move across the surface of the cell. The Schwartz Lab at the University of Colorado, Boulder, using Double Helix’s SPINDLE® imaging system, was […]


Tilted Light Sheet with DHO PSF Engineering for 3D Whole Cell and Sub-Cellular Super-Resolution Imaging

TILT3D enables low-background, 3D super-localization of single molecules on the surface of a cell as well as 3D super-resolution imaging inside of the cell.


Tilted Light Sheet examples

"TILT3D enables low-background, 3D super-localization of single molecules on the surface of a cell as well as 3D super-resolution imaging inside of the cell. The TILT3D setup enabled the researchers to image and reconstruct structures throughout whole mammalian cells including mitochondria within the cell as well as the full nuclear lamina."

Three-Dimensional Tracking of Interfacial Hopping Diffusion
Tilted Light Sheet with DHO PSF Engineering for 3D Whole Cell and Sub-Cellular Super-Resolution Imaging